Zhurnal Radioelektroniki - Journal of Radio Electronics. eISSN 1684-1719. 2023. №1
ContentsFull text in Russian (pdf)
DOI: https://doi.org/10.30898/1684-1719.2023.1.7
LABORATORY STAND BASED ON SQUID-MAGNETOMETERS
FOR STUDYING THE MAGNETIC PROPERTIES OF NANOMATERIALS
Yu.V. Maslennikov 1,2,3, V.Yu. Slobodchikov 2, V.A. Krymov 2,
A.D. Sukhodrovsky 2,4
1 Pushkov IZMIRAN, 108840, Russia, Moscow, Troitsk, Kaluzhskoe Hwy, 4
2 Kotelnikov IRE RAS, 125009, Russia, Moscow, Mokhovaya str. 11, b.7
3 CRYOTON Co. Ltd., 108840, Russia, Troitsk, Lesnaja str. b.4B
4 Bauman MSTU, 105005, Russia, Moscow, 2-nd Bauman str., 5, b.1
The paper was received October 31, 2022.
Abstract. The laboratory stand with the squid-based gradiometer was developed and tested in experimental studies of magnetic nanoparticles used in medicine. Two versions of the cryogenic probe were tested in investigations, the first of which included an additional XYZ squid-based magnetometer for "electronic" balancing of the input signal gradiometer in a uniform magnetic field. The second probe contained in its design movable trimmers with superconducting plates located in the area of the input loops of the gradiometer for its mechanical balancing. Both cryogenic probes demonstrated stable operation of the squid-based gradiometer at usual laboratory conditions without additional magnetic shielding. The stand was used to study the magnetization of aqueous suspensions of magnetite nanoparticles in various concentrations, which was induced using an uniform magnetic field with an amplitude of up to 15 milliTesla, created by a special system of Helmholtz coils at a frequency range of 4-12 Hz in the vertical and horizontal directions. The magnetic signals of nanoparticles were recorded using a second-order axial gradiometer in a «2:4:2» configuration with an input loop diameter of 8 mm and a base length of 29 mm. The experimental studies of the magnetization of aqueous suspensions of magnetite nanoparticles were aimed at estimating the limiting resolution of the SQUID gradiometer by the number of detected magnetic nanoparticles. The possibility of registering a magnetic signal from about 6 × 109 MNPs of magnetite 6 nm in size in a volume of 1 ml from a distance of about 20 mm from the receiving coils of the gradiometer was demonstrated. Dry liver extracts of small animals containing MNPs were also used as objects of study. Directions of further improvement the used instrumental elements and methods of magnetic measurements for increasing the sensitivity of squid-based gradiometers in experiments with MNPs are determined.
Key words: squid, gradiometer, magnetic nanoparticles, diagnostics of cancer.
Financing: This work was supported by the Russian Foundation for Basic Research (project No. 18-29-02087 mk).
Corresponding author: Maslennikov Yury Vasil’evich, cryoton@inbox.ru
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For citation:
Maslennikov Yu.V., Slobodchikov V.Yu., Krymov V.A., Sukhodrovsky A.D. Laboratory stand based on SQUID-magnetometers for studying the magnetic properties of nanomaterials. Zhurnal radioelektroniki [Journal of Radio Electronics] [online]. 2023. №1. https://doi.org/10.30898/1684-1719.2023.1.7 (In Russian)