Journal of Radio Electronics. eISSN 1684-1719. 2026. ¹3
Full text in Russian (pdf)
DOI: https://doi.org/10.30898/1684-1719.2026.3.8
EFFECT OF HIGH-INTENSITY
NANOSECOND ELECTROMAGNETIC PULSES
ON CANCEROUS CELLS IN VITRO
V.A. Vdovin1, A.D. Plyutinskaya2, A.A. Pankratov3, M.S. Vorontsova2,
S.A. Sapetskii1, R.A. Denisov1, V.A. Cherepenin1
1 Kotelnikov Institute of Radioengineering and Electronics of RAS,
125009, Russia, Moscow, Mokhovaya str., 11-72 Moscow Hertsen Research Institute of Oncology,
branch of the National Medical Radiology Research Center,
125284, Russia, Moscow, 2nd Botkinskii passage, 33 N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology,
branch of the National Medical Radiology Research Center,
105425, Russia, Moscow, 3rd Parkovaya str., 51, building 1
The paper was received March 30, 2026.
Abstract. For the purpose of evaluation of the effectiveness of nanosecond electromagnetic pulses application for the treatment of malignant neoplasms, experimental studies are conducted on Lewis lung carcinoma (LLC) cells. An equivalent electrical circuit is compiled for the pulse exposure target, which is a microplate with biological material (tumor cells) located between the electrodes of the experimental setup. The pulse transformation on the load is analyzed and a numerical evaluation of the characteristic physical quantities is performed. The results of biological experiments in vitro on the effect of nanosecond pulses on LLC tumor cells are presented, where the significant inhibition of tumor cell proliferation and an increase of efficiency with combined use with the antitumor drug Cisplatin-Teva are observed. The dependence of the cytotoxic effect on the repetition rate of the applied electrical pulses is also studied.
Key words: nanosecond pulses, electroporation, apoptosis, cytotoxic effect, proliferation inhibition.
Financing: The work was carried out under a state assignment from the Kotelnikov Institute of Radioengineering and Electronics of Russian Academy of Sciences
Corresponding author: Vdovin Vladimir Alexandrovich, vdv@cplire.ru
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For citation:
Vdovin V.A., Plyutinskaya A.D., Pankratov A.A., Vorontsova M.S., Sapetskii S.A., Denisov R.A., Cherepenin V.A. Effect of high-intensity nanosecond electromagnetic pulses on cancerous cells in vitro. // Journal of Radio Electronics. – 2026. – ¹. 3. https://doi.org/10.30898/1684-1719.2026.3.8 (In Russian)