BIOCOMPATIBLE NANOMATERIALS BASED ON OPAL MATRIXES

 

À. F. Belyanin ^1,2, A.S. Bagdasaryan ^2,3, Yu.V. Gulyaev³ , N.S. Sergeeva ⁴, S.A. Bagdasaryan ^1,2, E.R. Pavlyukova ³ 

¹ Central Research Technological Institute “Technomash”, 4, Ivan Franko Str., Moscow 121108, Russia

² Scientific Engineering Center “Technological developments of telecommunication and radio frequency identification”, JSC, 4 (1), Sukharevskaya Sq., Moscow 127051, Russia

³ Kotelnikov Institute of Radio-engineering and Electronics RAS, 11 (7), Mokhovaya Str., Moscow 125009, Russia

⁴ Herzen Moscow Oncology Research Center, National Medical Research Radiological Center, Ministry of Health RF, 3, 2nd Botkinskiy Proyezd, Moscow 125284, Russia

 

The paper is received on May 6, 2019

 

Abstract. The key problems for creation of bioartificial organs and tissues are the development of frame matrixes (carriers) for cells using nanoparticles of the different materials. To develop the adequate hybrid structures it is necessary to study the interaction of synthetic opal matrixes and natural analogues of similar materials, in particular, geyserite with cellular systems in order to create biocompatible materials for reconstructive plastic surgery. In the presented article the possibility to obtain and apply biocompatible opal matrixes (natural and artificial) for the cultivation of cellular systems, including multipotent mesenchymal stromal cells (MMSC): namely, the features of the formation and composition for "opal matrix (geyserite) - cell culture" type structure are considered. Investigation of biocompatibility for microparticles of opal matrixes in vivo was made for the following sample sample: fraction of opal matrix particles <40 µm, treatment temperature 790°C). The best matrix properties were demobnstrated in experiments. Executed investigations confirm the biocompatibility of opal matrixes (synthetic and natural) in a shape-shifter for biologically inert materials and the application in regenerative medicine.

Keywords: opal matrices, nanocomposites, multipotent mesenchymal stromal cells (MMSC).

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For citation:
À.F.Belyanin, A.S.Bagdasaryan, Yu.V.Gulyaev, N.S.Sergeeva, S.A.Bagdasaryan, E.R.Pavlyukova. Biocompatible nano materials based on opal matrixes. Zhurnal Radioelektroniki - Journal of Radio Electronics. 2019. No. 5. Available at http://jre.cplire.ru/jre/may19/3/text.pdf
DOI  10.30898/1684-1719.2019.5.3