Journal of Radio Electronics. eISSN 1684-1719. 2026. ¹5

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DOI: https://doi.org/10.30898/1684-1719.2026.5.11

 

 

 

the composition based on

an ytterbium porphyrin complex

for IR-luminescent diagnostics

and theranostics of inflammatory skin processes

 

I.P. Shilov 1, E.V. Orlova 2, V.D. Rumyantseva 1,3, M.I. Sekacheva 2

 

1 IRE Kotelnikov RAS, Fryazino branch,

141190, Russia, Fryazino, Vvedenskogo Sq. 1

2 I.M. Sechenov’ First Moscow State Medical University of the Russian Ministry of Health,

119435, Russia, Moscow, Bolshaya Pirogovskaya St., 2, 4

3MIREA – Russian Technological University,

119454, Russia, Moscow, Vernadskogo Ave., 78

 

The paper was received April 16, 2026.

 

Abstract. The potential of the pharmaceutical composition “Fluroscan”, based on the dipotassium salt of the Yb complex of 2,4-di(α-methoxyethyl)deuteroporphyrin IX, for IR luminescence diagnostics and theranostics of skin toxicity in the form of rosacea-like dermatitis is demonstrated. The prototype of a fiber-optic laser fluorimeter (developed in the V.A. Kotelnikov Institute of Radioelectronics RAS) operating in the spectral range of 900-1100 nm at an optical power of up to 10 mW was used for IR luminescence diagnostics and treatment monitoring. Patients were treated using a SOR Internacional S.A. irradiation lamp in the red spectral range (620-640 nm). It was found that a decrease in luminescence intensity after a therapy course indicated a decrease in metabolic activity and confirmed the effectiveness of the treatment.

Key words: 2,4-di(α-methoxyethyl)deuteroporphyrin IX, laser-fiber fluorimeter, Fluroscan gel, photodynamic therapy, theranostics, IR luminescent diagnostics.

Financing: The work was carried out according to the State Assignment of the Kotelnikov IRE RAS.

Corresponding author: Shilov Igor Petrovitch, laserlab@ms.ire.rssi.ru

 

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For citation:

Shilov I.P., Orlova E.V., Rumyantseva V.D., Sekacheva M.I. The composition based on an ytterbium porphyrin complex for IR-luminescent diagnostics and theranostics of inflammatory skin processes // Journal of Radio Electronics. – 2026. – ¹. 5. https://doi.org/10.30898/1684-1719.2026.5.11 (In Russian)