Journal of Radio Electronics. eISSN 1684-1719. 2025. ¹11
Full text in Russian (pdf)
DOI: https://doi.org/10.30898/1684-1719.2025.11.46
INTERACTION OF MAGNETITE NANOPARTICLES
WITH A BILAYER LIPID MEMBRANE
I.V. Grigoryan1,2, I.V. Taranov2, I.M. Le-Deigen3, E.D. Borisova2,4, A.A. Anosov2,4,
I.M. Kolmogorov3, I.D. Kravtsov1,2, A.M. Adelyanov1, A.A. Yaroslavov3,
V.V. Spiridonov3, G.B. Khomutov1,2, V.A. Cherepenin2
1Faculty of Physics M.V. Lomonosov Moscow State University,
119991 Moscow, Leninskie Gory, b.12Kotelnikov Institute of Radio Engineering and Electronics of RAS,,
Moscow, Russia Mokhovaya str., 11, b.73Faculty of Chemistry M.V. Lomonosov Moscow State University,
119991 Moscow, Leninskie Gory, b.14I.M. Sechenov First Moscow State Medical University (Sechenov University)
119435, Russia, Moscow, Trubetskaya str., 8, b. 2
The paper was received November 28, 2025.
Abstract. This study investigates the mechanisms of interaction between superparamagnetic magnetite nanoparticles (MNPs) and a lipid bilayer membrane (BLM). Ligand-free polar magnetite nanoparticles, which form a colloidal suspension in the aqueous phase, can penetrate the BLM without compromising its integrity. As magnetite MNPs pass through the membrane, complexes of the nanoparticles with lipid molecules are formed, which are detected in the aqueous phase behind the membrane. In this study, independent experimental methods of structure-functional diagnostics, including FTIR spectroscopy, dynamic light scattering, scanning transmission electron microscopy (STEM), and energy-dispersive X-ray (EDX) spectroscopy, were used to characterize nanocomposite complexes adsorbed on novel magnetic traps installed behind a planar azolectin BLM. The obtained results indicate that the resulting complexes are polydisperse with characteristic sizes in the range of 10–300 nm and have an iron-containing core surrounded by a lipid shell in the form of bilayers or multilayers of lipid molecules. Using the Langmuir-Blodgett method, the interaction of colloidal magnetite MNPs in the aqueous phase with lipid azolectin monolayers on the surface of the aqueous subphase in an external nonuniform magnetic field was studied. The corresponding monolayer Langmuir films, deposited on a solid mica substrate using the Schaeffer and Langmuir-Blodgett methods, were studied by atomic force microscopy (AFM) in tapping mode. The results of a topographic analysis of the structure of the obtained nanocomposite Langmuir films containing complexes of magnetite nanoparticles and azolectin molecules are consistent with the above-mentioned structural analysis of nanocomposite complexes formed during the interaction of magnetite nanoparticles with a bilayer lipid membrane.
Key words: bilayer lipid membrane, colloidal magnetite nanoparticles, membrane penetration of colloidal particles, nanoparticle-lipid complexes, scanning transmission electron microscopy, energy-dispersive X-ray spectroscopy, Langmuir monolayers and films.
Financing: The work was carried out within the framework of state assignment FFWZ 2025-0013
Corresponding author: Taranov Igor Vladimirovich, i.v.t@bk.ru
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For citation:
Grigoryan I.V., Taranov I.V., Le-Deigen I.M., Borisova E.D., Anosov A.A., Kolmogorov I.M., Kravtsov I.D., Adelyanov A.M., Yaroslavov A.A., Spiridonov V.V., Khomutov G.B., Cherepenin V.A. Interaction of magnetite nanoparticles with a bilayer lipid membrane. // Journal of Radio Electronics. – 2025. – ¹. 11. https://doi.org/10.30898/1684-1719.2025.11.46 (In Russian)