Local NMR spectroscopy in a study of head brain ischemia
M. V.
Gulyaev 1, L. V. Gubskiy 2, E. A. Cherkashova
2, N. V. Anisimov 1, Jaw
Fushan 3, Yu. A. Pirogov 1
1
M. V. Lomonosov Moscow state university
2
N. I. Pirogov Russian national research medical university
3
National university of Taiwan
Received
January 24, 2013
Abstract. Morphological and
metabolic peculiarities of ischemia formations in the rat head brain were
studied by local NMR spectroscopy method on the 7-T biospectral scanner Bruker
BioSpec 70/30 URS. Measured proton spectra displayed: after middle brain artery
occlusion, formed ischemia seat changes metabolic processes in damage place
cardinally. Reduction of kreatine, remarkable increasing lactate and lipids,
and growth of lactate/choline relation have place after middle brain artery
occlusion. These indications allow with high reliability to determine stages of
ischemia regeneration of healthy tissues after brain stroke. Developed
noninvasive spectroscopy method in vivo in combination with MRI regime
allows to substitute for a surgical biopsy of any new formation in human and
animal organisms.
Key words: medical physics,
magnetic resonance imaging, NMR radio spectroscopy, head brain ischemia, brain
stroke, biospectral MRI scanner, metabolite, biopsy.