ULTRA
SHORT ELECTRIC PULSES REMOTE ACTIVATION OF LIPOSOMAL CAPSULES CONTAINING
GOLD NANORODS
Yu. V. Gulyaev1, V. A. Cherepenin1, I. V. Taranov1,
V. A. Vdovin1, A. A.Yaroslavov1, 2, V.
P. Kim1, 3, G. B. Khomutov1, 3
1 – Kotel’nikov Institute of Radio Engineering and Electronics of RAS
2 - Faculty of Chemistry, M.V. Lomonosov Moscow State University
3 – Faculty of Physics, M.V. Lomonosov Moscow State University
The paper is
received on November 2, 2015
Abstract.
The effect of decapsulation of nanocomposite
liposomal capsules containing anisotropic gold nanoparticles (nanorods) caused
by their treatment using ultrashort external electric field pulses have been
discovered. The mechanism of the liposome capsule shell destruction in the pole
areas of conductive gold nanorods caused by external pulsed electrical
stimulation was described. An expression for the
critical value of the applied pulsed electric field which determines the
threshold for the onset of the decapsulation effect have been obtained. The
theoretical calculated numerical value of threshold pulsed electric field was
consistent with the obtained experimental data. It was shown experimentally
that the observed decapsulation effect was caused by the presence of gold
nanorods bound with the liposomal capsule shell, and that the
decapsulation effect did not occur in liposomes in the absence of
gold nanorods.
Keywords:
capsule, liposomes, structure, gold nanorods,
polyelectrolytes, pulse electric field.