Zhurnal Radioelektroniki - Journal of Radio Electronics. eISSN 1684-1719. 2020. No. 4

Full text in Russian (pdf)
Russian page


DOI 10.30898/1684-1719.2020.4.14

UDC 539.2




A. F. Belyanin 1, A. S. Bagdasaryan 2,3, N. S. Sergeeva 4, S. A. Bagdasaryan 2, E. R. Pavlyukova 3

 1 Central Research Technological Institute “Technomash”, Ivan Franko Str., 4, Moscow, 121108, Russia

2 Scientific Engineering Center “Technological developments of telecommunication and radio frequency identification”, JSC, Sukharevskaya Sq.,4-1 Moscow, 127051, Russia

3 Kotelnikov Institute of Radioengineering and Electronics of Russian Academy of Sciences, Mokhovaya Str., 11-1, Moscow, 125009, Russia

4 Hertsen Moscow Oncology Research Center, 3, Vtoroy Botkinskiy Proyezd, Moscow, 125284, Russia


The paper is received on April 21, 2020


Abstract. Construction of bio-artificial organs and tissues in reconstructive plastic surgery depends largely on the development of the cell scaffolds using micro- and nanoparticles of different nature. In the present paper, we consider the interaction of microparticles of opal matrix powders (regular packings of spherical nanoparticles of amorphous SiO2 with a diameter of 200–260 nm) and geyserite (a natural analogue of opal matrixes) with cell systems. The biocompatibility of opal matrixes (geyserite) and the cell growth dynamics in an immortalized human fibroblast model were evaluated. The features of the formation and structure of the biocomposite material “opal matrix (geyserite) - cell culture” have been considered. It was demonstrated that cell reproduction take place on the surface of opal matrix powder (geyserite) microparticles with a crosswise size from units up to tens of micrometers. Given “in vitro” investigation results of the acute cytotoxicity and matrix (adhesive) properties of opal matrices and geyserite microparticles, as well as “in vivo” of their biocompatibility, make us possible to consider the formation of three-dimensional composite by cell systems and microparticles as an element of self-organization.

The stability of the three-dimensional two-phase structure (“opal matrix (geyserite) - cell culture”) has been determined, due to the fact that the solid phase (opal matrix powder or geyserite microparticles) reinforces the biological mass, creating the possibility of volumetric formation of the last one.

Keywords: opal matrixes, geyserites, biocomposite materials, scanning electron microscopy (SEM).


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 For citation:

Belyanin A.F., Bagdasaryan A.S., Sergeeva N.S., Bagdasaryan S.A., Pavlyukova E.R. Study of the structure of biocompatible nanomaterials based on silicon dioxide. Zhurnal Radioelektroniki - Journal of Radio Electronics. 2020. No. 4. Available at http://jre.cplire.ru/jre/apr20/14/text.pdf.  DOI 10.30898/1684-1719.2020.4.14