Application of terahertz spectroscopy for aqueous solutions of biomolecules study

 

A. V. Semenova^1,2, Yu. S. Guseva^1,2, A. N. Panin², V. L. Vaks^1,2

¹Lobachevsky State University of Nizhny Novgorod

²Institute for Physics of Microstructures of RAS

 

 The paper is received on January 25, 2016

 

Abstract. This work is devoted to developing the precise terahertz spectroscopy of aqueous solutions containing biological molecules for applications of non-invasive biomedical diagnostics. Spectra of the herring`s DNA and insulin-based drug were under study experimentally. An absorption spectrum of DNA was simulated in the terahertz range. We compared the spectra obtained with terahertz high-resolution spectroscopy based on microwave approach with such given by standard quasi-optical methods. Standard methods of THz spectroscopy are shown to have insufficient spectral resolution for studying the fine structure of biological molecules spectra.

Key words: terahertz frequency range, high-resolution spectroscopy, biomolecules, spectra of liquids, low- frequency oscillations, modeling of DNA`s dynamics.