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High precise THz spectroscopy forsolutions of medical and biology problems


V. L.Vaks 1,2, E. G. Domracheva 1,2, E. A.Sobakinskaya 1,2, M. B.Chernyaeva 1,2, V. A.Anfertev 1,2, A.V.Semenova 1,2, Yu. S. Shatrova1,2

1Institute for Physics of Microstructures of RAS

2Lobachevsky State University of Nizhny Novgorod


The paper is received on January 21, 2014


Abstract: One of the most prospective methods of non-invasive diagnostics is the exhaled breath analysis which can be used not only for detecting various diseases and prediction of organism response on concrete medical treatment, but also for monitoring of therapy efficiency. Based on the measuring of gas-markers concentration one can diagnose a number of serious diseases including gastrointestinal, oncological, neuropsychic and ENT diseases. Among the variety of methods of exhaled breath analysis the most prospective are the spectroscopic ones, and namely terahertz spectroscopy. The undoubted advantages of terahertz gas spectroscopy are the high sensitivity and resolution simultaneously. In the paper the results of exhaled breath spectroscopic investigations with using the THz spectrometers developed for non-invasive medical diagnostics of diabetes, pre-cancer states and oncological diseases of gastrointestinal tract, as well as for monitoring the efficiency of radiotherapy on dynamics of concentration are presented. The fine structure of DNA spectrum in the frequency range of 300-375 GHz with using the high-precision spectrometer based on BWO frequency synthesizer and high quality resonator was studied.

Key words: terahertz frequency range, high precise non-stationary spectroscopy, non-invasive medical diagnostics, exhaled breath, gas-marker.