Zhurnal Radioelektroniki - Journal of Radio Electronics. eISSN 1684-1719. 2020. No. 9
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DOI  https://doi.org/10.30898/1684-1719.2020.9.9

UDC 666.189.2

 

 Spectral-optical studies of the photoactivity of the ytterbium complex 2,4-di(α-methoxyethyl)deuteroporphyrin IX — a promising substance for NIR luminescence diagnostics of cancer

 

I. P. Shilov, A. V. Ivanov2,3

1 Kotelnikov Institute of Radio Engineering and Electronics RAS, Fryazino branch, Akad. Vvedenskogo sq., 1, Fryazino, Moscow region 141190, Russia

2 Blokhin’ National Medical Research Center of Oncology îf the Ministry of Health of the Russian Federation, Kashirskoye shosse, 24, Moscow 115478, Russia

3 Skobelkin’ State Scientific Center of Laser Medicine FMBA, Studencheskaya str., 40, Moscow 121165, Russia

 

The paper is received on September 10, 2020

 

Abstract. The spectral optical study of photoactivity of ytterbium complex of 2,4-di(α-methoxyethyl)deuteroporphyrin IX (Yb-DMDP), perspective substance for IR-luminescent cancer diagnostics with enhanced spectral-kinetic characteristics, is carried out. The dynamics of singlet oxygen photosensitized formation for the Yb-DMDP and for the metal-free porphyrin under laser excitation using a highly sensitive laser fluorimeter, is studied. It was shown that quantum yield of a singlet oxygen generation for Yb-DMDP (11%) is significantly less than for the metal-free porphyrin (40%). This fact experimentally confirms a Yb-DMDP low photoactivity. Secondly, the Yb-DMDP low photoactivity was confirmed by the MTT-method. It was established that Yb-DMDP possesses low cytophototoxic properties (IC50 value ~ 10–5,5 Ì/L). Thus, Yb-DMDP low photochemical activity and phototoxicity are proved.

Key words: ytterbium complex of 2,4-di(α-methoxyethyl)deuteroporphyrin IX, photoactivity, luminescence, singlet oxygen, quantum yield, laser fluorimeter, phototoxicity.

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For citation:

Shilov I.P., Ivanov A.V. Spectral-optical studies of the photoactivity of the ytterbium complex 2,4-di(α-methoxyethyl)deuteroporphyrin IX — a promising substance for NIR luminescence diagnostics of cancer. Zhurnal Radioelektroniki - Journal of Radio Electronics. 2020. No.9. https://doi.org/10.30898/1684-1719.2020.9.9 (In Russian)