Диагностический измерительный стенд для исследования спектрально-люминесцентных свойств малотоксичных фотосенсибилизаторов на основе комплексов порфиринов с иттербием

Abstract

Porphyrins are known to have an ability to accumulate in malignant tumors, which had led to their use in photodynamic cancer therapy. As for early cancer diagnostics, photosensitizers based on metal (in particular lanthanide) complexes of porphyrins, seem to be the most promising. Among the lanthanides, the ytterbium ion has the highest internal quantum yield (up to 4%), which is why its low-toxic porphyrins complexes may be used in NIR-luminescent diagnostics. The laser measuring test-bench with excitation in visible range of spectrum (wavelength ~ 530 nm) designed for the analysis of spectral-luminescent and kinetics characteristics of ytterbium porphyrin complexes, was developed. Photophysical properties of lanthanide porphyrin complexes emitting in NIR-spectral range, are considered. The DMSO solvent influence on the ytterbium ion luminescence was studied in comparison with aqueous solutions. It was shown that the luminescence intensity greatly increases with DMSO concentration increase. Yb-porphyrin сomplexes in DMSO solution with concentration of 20-30%, allowed in medicine, are of practical interest concerning intravenous injections. For such DMSO concentrations Yb luminescence lifetime is ~ 5-10 μs. A lifetime for complex of 5,10,15,20-tetra(1-N-( p -fluorophenyl)-3( o -chlorophenyl)pyrazol-4-yl)porphyrin was found to be about 20 μs, which is the most high luminescence lifetime among ytterbium complexes synthesized earlier. In the future, this can lead to a significant reduction in а drug dose with а possible saving of diagnostic contrast ratio values.

• измерительный стенд
• люминесценция
• БИК-люминесцентная диагностика
• иттербиевые комплексы порфиринов
• measuring stand
• luminescence
• near infrared luminescent diagnostics
• ytterbium complexes of porphyrins

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References

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