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Journal of Radio Electronics Online scientific journal · eISSN 1684-1719
2026, № 3 · BIOMEDICAL RADIO ELECTRONICS

Effect of high-intensity nanosecond electromagnetic pulses on cancerous cells in vitro

V.A. Vdovin1, A.D. Plyutinskaya2, A.A. Pankratov3, M.S. Vorontsova2, S.A. Sapetskii1, R.A. Denisov1, V.A. Cherepenin1

1 Kotelnikov IRE RAS, Moscow, Russia
2 Moscow Hertsen Research Institute of Oncology, Moscow, Russia
3 N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology, Moscow, Russia
Full text DOI: 10.30898/1684-1719.2026.3.8 UDC 57.085.2+616-006+621.373 EDN BMCRTB

Abstract

For the purpose of evaluation of the effectiveness of nanosecond electromagnetic pulses application for the treatment of malignant neoplasms, experimental studies are conducted on Lewis lung carcinoma (LLC) cells. An equivalent electrical circuit is compiled for the pulse exposure target, which is a microplate with biological material (tumor cells) located between the electrodes of the experimental setup. The pulse transformation on the load is analyzed and a numerical evaluation of the characteristic physical quantities is performed. The results of biological experiments in vitro on the effect of nanosecond pulses on LLC tumor cells are presented, where the significant inhibition of tumor cell proliferation and an increase of efficiency with combined use with the antitumor drug Cisplatin-Teva are observed. The dependence of the cytotoxic effect on the repetition rate of the applied electrical pulses is also studied.

  • nanosecond pulses
  • electroporation
  • apoptosis
  • cytotoxic effect
  • proliferation inhibition
Аннотация (на русском)

Влияние мощных электромагнитных импульсов наносекундной длительности на опухолевые клетки в системе in vitro

В контексте оценки использования наносекундных электромагнитных импульсов для лечения злокачественных новообразований проводятся экспериментальные исследования на клетках карциномы лёгкого Льюиса (LLC). Для области воздействия, представляющей собой находящийся между электродами экспериментальной установки микропланшет с биологическим материалом (опухолевыми клетками), составляется эквивалентная электрическая схема, производится анализ трансформации импульса на нагрузке и численная оценка характерных физических величин. Приводятся результаты биологических экспериментов в системе in vitro по воздействию наносекундными импульсами на опухолевые клетки культуры LLC, где отмечается как собственное цитотоксическое действие применяемых импульсов, приводящее к значимому ингибированию пролиферации опухолевых клеток, так и увеличение эффективности при сочетанном применении с противоопухолевым препаратом Цисплатин-Тева. Исследуется также зависимость цитотоксического эффекта от частоты повторения подаваемых электрических импульсов.

For citation

Vdovin V.A., Plyutinskaya A.D., Pankratov A.A., Vorontsova M.S., Sapetskii S.A., Denisov R.A., Cherepenin V.A. Effect of high-intensity nanosecond electromagnetic pulses on cancerous cells in vitro // Journal of Radio Electronics. – 2026. – No. 3. https://doi.org/10.30898/1684-1719.2026.3.8

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