Radiothermometric monitoring during skin cancer theranostics using photodynamic therapy in the porphyrin absorption band

Marechek, S. V.; Shilov, I. P.; Novichikhin, E. P.; Gorshkova, A. S.; Ivanov, A. V.

doi:10.30898/1684-1719.2026.9.10

S.V. Marechek¹, I.P. Shilov¹, E.P. Novichikhin¹, A.S. Gorshkova¹, A.V. Ivanov²

Abstract

The temperature dynamics of the malignant neoplasms primary node in laboratory animals by radiothermometry during skin cancer theranostics using photodynamic therapy (PDT) in a porphyrin absorption band was studied. An adapted technology for monitoring temperature fluctuations deep within biological tissues, based on a multichannel hardware and software system, was used. C57Bl laboratory mice with developed transplantable Lewis lung epidermoid carcinoma were used in the experiments. A device with ultra-bright AFS series LEDs operating at a wavelength of 635 nm in the metal-free porphyrin absorption band was used as a radiation source. It has been demonstrated that an adapted radiothermometry technique effectively determines the temperature profile of malignant tumors during PDT. The information obtained can be used to adjust the regimen and dose of LED light for PDT, as well as to develop methods for combining thermotherapy and PDT.

Аннотация (на русском)

Радиотермометрический мониторинг в процессе тераностики рака кожи с использованием фотодинамической терапии в полосе поглощения порфирина

Проведено изучение динамики температурного статуса первичного узла злокачественных новообразований лабораторных животных методом радиотермометрии в условиях проведения тераностики рака кожи с использованием фотодинамической терапии (ФДТ) в полосе поглощения порфирина. В исследовании применяли адаптированную технологию контроля флуктуаций температуры в глубине биологических тканей на основе многоканального аппаратно-программного комплекса. В экспериментах использовали лабораторных мышей линии C57Bl с развившейся трансплантируемой эпидермоидной карциномой легкого Льюиса. В качестве источника излучения использовали аппарат на сверхъярких светодиодах серии «АФС» на длине волны 635 нм в полосе поглощения безметального порфирина. Показано, что адаптированная методика радиотермометрии позволяет эффективно определять температурный профиль злокачественных новообразований при проведении ФДТ. Полученная информация может быть использована для коррекции режима и дозы светодиодного воздействия для ФДТ, а также при разработке методов сочетанной термотерапии и ФДТ.

Funding

The work was carried out according to the State Assignment of the V.A. Kotelnikov IRE RAS

For citation

Marechek S.V., Shilov I.P., Novichikhin E.P., Gorshkova A.S., Ivanov A.V. Radiothermometric monitoring during skin cancer theranostics using photodynamic therapy in the porphyrin absorption band // Journal of Radio Electronics. – 2026. – № 9. https://doi.org/10.30898/1684-1719.2026.9.10 (In Russian)

References

Baetke S.C., Lammers T., Kiessling F. Applications of nanoparticles for diagnosis and therapy of cancer // British J. Radiology. – 2015. – V. 88. – №. 1054. – P. 20150207. https://doi.org/10.1259/bjr.20150207
Golovin Yu. I. et al. New approaches to nanotheranostics: polyfunctional magnetic nanoparticles activated by a non-heating low-frequency magnetic field control a biochemical system with molecular locality and selectivity // Nanotechnologies in Russia. – 2018. – V. 13. – №. 5-6. – P. 3-25. (in Russian)
Khlebtsov B. et al. Nanocomposites containing silica-coated gold–silver nanocages and Yb–2, 4-Dimethoxyhematoporphyrin: Multifunctional capability of IR-luminescence detection, photosensitization, and photothermolysis // ACS nano. – 2011. – V. 5. – №. 9. – P. 7077-7089. https://doi.org/10.1021/nn2017974
Ivanov A.V., Shilov I.P., Rumyantseva V.D., Alekseev Yu.V. Ytterbium complexes of porphyrins in luminescent diagnostics and theranostics of cancer //XXXI International Conference "Lasers in Science, Technology and Medicine": Collection of scientific papers. Volume 31 edited by Petrov V.A. – Moscow: Moscow Scientific-Technical Society of Radio Engineering, Electronics and Communication named after A.S. Popov. October 28-30, 2020. – P. 148-149. (in Russian)
Shilov I. P., Kochmarev L. Yu., Novichikhin E. P. Laser-fiber fluorimeter for NIR-luminescent diagnostics of neoplasms of the skin and mucous membranes // Biomedical Engineering. – 2020. – №. 6. – P. 1-4. (in Russian)
Alekseev Y. V. et al. Luminescent diagnostics of skin defects in the near-infrared range // Journal of Biomedical Optics. – 2017. – V. 22. – №. 9. – P. 098001-098001. https://doi.org/10.1117/1.JBO.22.9.098001
Polyakov V. M. Measurements of absolute thermodynamic temperatures of biological objects by radiophysical methods // Radio Engineering. – 1998. – №. 8. – P. 88-94. (in Russian)
Basharinov A. E. et al. Measurement of radiothermal and plasma radiation in the microwave range. – Soviet radio, 1968. 390 pp. (in Russian)
Marechek S. V., Polyakov V. M. Influence of the structure of biological tissue on the results of microwave thermometric measurements // Journal Achievements of Modern Radioelectronics. – 2001. – №. 11. – P. 21-30. (in Russian)